Quetiapine Fumarate 400mg

Quetiapine Fumarate 400mg is an atypical antipsychotic used in the management of schizophrenia, bipolar disorder, and as an adjunct in depression.

At this mid-to-high therapeutic dose, it blocks dopamine D2 and serotonin 5-HT2A receptors, helping to control psychosis, mood instability, and agitation. Quetiapine additionally has sedating properties, which can be beneficial for managing insomnia and acute agitation in psychiatric contexts.

Possible side effects include weight gain, metabolic changes, somnolence, orthostatic hypotension, and a lower risk of extrapyramidal symptoms compared to typical antipsychotics. It should be used cautiously in the elderly due to increased risk of cerebrovascular events. Abuse potential is low, but the medication is sometimes misused for sedation. Slow tapering is advised to avoid rebound symptoms.

• Primary uses: Schizophrenia, bipolar disorder, adjunctive treatment for depression.
• Onset: Sedation in hours; antipsychotic effects over days to weeks.
• Warnings: Monitor for metabolic and cardiovascular effects.
• Risks: Weight gain, metabolic syndrome, drowsiness, rare misuse for sedation.